PUBLICATIONS

Our team has published extensively in an effort to uncover a link between vitamin D and diabetes. We have published original manuscripts (original trials, ancillary analyses of completed trials, observational studies, systematic reviews), book chapters and editorials.

Draw your own conclusions

Post-randomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, to overcome this challenge, we calculated intra-trial vitamin D exposure as the cumulative rolling mean of annual serum 25(OH)D measurements. Among participants at risk for diabetes treated with vitamin D, those who maintained intra-trial blood 25(OH)D levels of 40-49 ng/mL (100–124 nmol/L) had a 52% lower risk of developing diabetes compared to those who maintained a level of 20-29 ng/mL (50–74 nmol/L). Those who maintained blood 25(OH)D levels equal to or greater than 50 ng/mL (125 nmol/L) had a 71%, lower risk of developing diabetes. We concluded that daily vitamin D supplementation to maintain a blood 25(OH)D level greater than 40 ng/mL (100 nmol/L) is a promising approach to reducing the risk of diabetes in adults with prediabetes.

Featured Publication

Original Manuscripts

  • Pittas AG, Jorde R, Kawahara T, Dawson-Hughes B. Response to Letter to the Editor from Dalan: Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D? JCEM. 2021 Mar 25;106(4)e1928-e1929. [PMID:33377909] [PMCID: PMC7993574].
  • Dawson-Hughes B, Staten MA, Knowler WC, Nelson J, Vickery EM, LeBlanc ES, Neff LM, Park J and Pittas AG. Intra-trial exposure to vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the vitamin D and type 2 diabetes (D2d) study. Diabetes Care. 2020 Dec 43(12):2916-2922. [PMID:33020052] [PMCID: PMC7770274].
  • Pittas AG, Jorde R, Kawahar T and Dawson-Hughes B. Vitamin D supplementation for prevention of type 2 diabetes mellitus. To D or not to D? Mini-Review. JCEM. 2020 Dec 1;105(12):3721-33. [PMID:32844212] [PMCID:PMC7571449].
  • Pittas AG and Balk EM. Untangling the Gordian Knot of vitamin D supplementation and type 2 diabetes prevention. Diabetes Care. 2020 Jul;43(7):1375-1377. [PMID:33534725] [PMCID:PMC8051406 (available on 2021-07-01)].
  • Pittas AG, Dawson-Hughes B and Staten M. Vitamin D supplementation and prevention of type 2 diabetes. Reply. N Engl J Med. 2019 Oct 31;381(18);1785-1786. [PMID:31665590].
  • Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, Brodsky I, Ceglia L, Chadha C, Chatterjee R, Desouza C, Dolor R, Foreyt J, Fuss P, Ghazi A, Hsia DS, Johnson KC, Kashyap SR, Kim S, LeBlanc ES, Lewis MR, Liao E, Neff LM, Nelson J, O’Neil P, Park J, Peters A, Phillips LS, Pratley R, Raskin P, Rasouli N, Robbins D, Rosen C, Vickery EM, Staten M; D2d Research Group. Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med. 2019 Aug 8:381(6):520-530. [PMID:31173679] [PMCID:PMC6993875].
  • Angellotti E, D’Alessio D, Dawson-Hughes B, Chu Y, Nelson J, Hu P, Cohen RM and Pittas AG. Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clin Nutr. 2019 Oct;38(5):2449-2453. [PMID:30352748] [PMCID:PMC6456440].
  • Ebeling PR, Adler RA, Jones G, Liberman UA, Mazziotti G, Minisola S, Munns CF, Napoli N, Pittas AG, Giustina A, Bilezikian JP and Rizzoli R. MANAGEMENT OF ENDOCRINE DISEASE: Therapeutics of vitamin D. European Journal of Endocrinology. 2018: 170:5: R239-259. [PMID:30131372].
  • LeBlanc ES, Pratley RE, Dawson-Hughes B, Staten MA, Sheehan PR, Lewis MR, Peters A, Kim SH, Chatterjee R, Aroda VR, Chadha C, Neff LM, Brodsky IG, Rosen C, Desouza CV, Foreyt JP, Hsia DS, Johnson KC, Raskin P, Kashyap SR, O’Neil PO, Phillips LS, Rasouli N, Liao EP, Robbins DC and Pittas AG for the D2d Research Group. Baseline characteristics of the vitamin D and type 2 diabetes (D2d) study: A contemporary prediabetes cohort that will inform diabetes prevention efforts. Diabetes Care. August 2018: 41: 1590-1599. [PMID:29941495] [PMCID:PMC6054501].
  • Angellotti E, D’Alessio D, Dawson-Hughes B, Nelson N, Cohen RM, Gastaldelli A and Pittas AG. Vitamin D supplementation in patients with type 2 diabetes: the vitamin D for established type 2 diabetes (DDM2) study. J Endocr Soc. 2018 Apr 1; 2(4): 310–321. [PMID:29577107] [PMCID:PMC5848819].
  • Nunez-Lopez YO, Pittas AG, Pratley R and Seyhan A. Circulating levels of miR-7, miR-152, and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control. The Journal of Nutritional Biochemistry. 2017 Nov;49:117-122. [PMID:28945992].
  • Angellotti E and Pittas AG. The role of vitamin D in the prevention of type 2 diabetes. To D or not to D? Endocrinology. 2017 May 8. [PMID:28486616][PMCID:PMC5505219].
  • Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B and Pittas AG. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program. Eur J Nutr. 2017 Feb; 56(1):161-170. [PMID:26525562] [PMCID:PMC5121080]
  • Nunez-Lopez YO, Pittas AG, Pratley R and Seyhan A. Circulating levels of miR-7, miR-152, and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control. The Journal of Nutritional Biochemistry. 2017. [PMID:28945992].
  • Alzaman NS, Dawson-Hughes B, Nelson J, D’Alessio D and Pittas AG. Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation. AJCN. 2016:104(1):205-14. [PMID:27194308] [PMCID:PMC4919528].
  • Pittas AG, Dawson-Hughes B, Sheehan PR, Rosen CJ, Ware JH, Knowler WC, Staten MA and the D2d Research Group. Rationale and Design of the Vitamin D and Type 2 Diabetes Study: A Diabetes Prevention Trial. Diabetes Care. 2014 Dec;37(12):3227-34. [PMID:25205139] [PMCID:PMC4237973].
  • Muscogiuri G, Mitri J, Mathieu C, Badenhoop K, Tamer G, Orio F, Mezza T, Vieth R, Colao AA, and Pittas AG. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol. 2014 Sep;171(3):R101-10. [PMID:24872497].
  • Mitri J and Pittas AG. Vitamin D and diabetesEndocrinol Metab Clin N Am. 2014: Mar;43(1):205-32. [PMID:24582099] [PMCID:PMC3942667].
  • Mitri J, Nelson J, Ruthazer R, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B and Pittas AG. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program. EJCN. 2014 Mar;68(3):376-83. [PMID:24448494] [PMCID:PMC4091839].
  • Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann NY Acad Sci. 2013 May:1387:45-58. [PMID:23682710] [PMCID:PMC3717170].
  • Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB and Dawson-Hughes B. Vitamin D status and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program randomized controlled trial. Diabetes Care. 2012:35(3):565-573. [PMID:22323410] [PMCID:PMC3322702].
  • Harris SS, Pittas AG and Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes, Obesity and Metabolism. 2012. [PMID:22486948].
  • Liu E, McKeown NM, Pittas AG, Meigs JB, Economos CD, Booth SL and Jacques PF. Predicted 25-hydroxyvitamin D score and change in fasting plasma glucose in the Framingham offspring study. EJCN. 2011 19 October 2011; doi:10.1038/ejcn.2011.181. [PMID:22009071] [PMCID:PMC3796766].
  • Mitri J, Dawson-Hughes B and Pittas AG. The effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity and glycemia in adults at high risk for diabetes. The CaDDM randomized controlled trial. Am J Clin Nutr. 94(2): 486-494. 2011. [PMID:21715514] [PMCID:PMC3142723].
  • Mitri J, Muraru MD and Pittas AG. Vitamin D and type 2 diabetes. A systematic review. EJCN. 2011: 65(9): 1005-1015 [PMID:21731035] [PMCID:PMC4066381].
  • Pittas AG, Qi S, Manson JE, Dawson-Hughes B and Hu FB. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care. 2010:33(9):2021-3. [PMID:20805275] [PMCID:PMC2928356].
  • Pittas AG. Vitamin D and Cardiometabolic Disease. Functional Food Reviews. 2010:2:2 (Summer 2010)
  • Liu E, Meigs JB, Pittas AG, Economos CD, McKeown NM, Booth SL and Jacques PF. Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. AJCN. 2010;91(6):1627-33. [PMID:20392893] [PMCID: PMC2869511].
  • Pittas AG and Dawson-Hughes B. Vitamin D and Diabetes. J Steroid Biochem Mol Biol. 2010, Jul:121(1-2)425-9 [PMID:20304061] [PMCID:PMC2900448].
  • Pittas AG, Chung M, Trikalinos TA, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J and Balk E. Vitamin D and Cardiometabolic Outcomes: A Systematic Review. Ann Intern Med. 2010:152(5):307-314. [PMID:20194237] [PMCID:PMC3211092].
  • Pittas AG, Laskowski U, Kos L and Saltzman E. The role of vitamin D in adults requiring nutrition support. J Parenter Enteral Nutr. 2010 Jan-Feb;34(1)70-80 [PMID:19875748][PMCID:PMC2857395].
  • Liu E, Meigs JB, Pittas AG, McKeown NM, Economos CD, Booth SL, Jacques PF. Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistance phenotype in non-diabetic adults. J. Nutr. 2009 Feb:139(2):329-34. Epub 2008 Dec 23. [PMID:19106328] [PMCID:PMC2646208].
  • Peechakara SV and Pittas AG. Vitamin D as a potential modifier of diabetes risk. Nature Reviews Endocrinology. 2008:4(4):182-183. [PMID:18283325].
  • Pittas AG, Harris SS, Stark, PC and Dawson-Hughes B. The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Non-diabetic Adults. Diabetes Care. 2007 Apr:30(4):980-6; Epub 2007 Feb 2. [PMID:17277040].
  • Pittas AG, Lau J, Hu F and Dawson-Hughes B. The Role of Vitamin D and Calcium in type 2 diabetes. A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2007:92:2017-2029. Epub 2007 Mar 27. [PMID:17389701] [PCID:PMC2085234].
  • Pittas AG, Dawson-Hughes B, Li T, Willett WC, Van Dam RV, Manson JE and Hu FB. Vitamin D and Calcium Intake in Relation to type 2 Diabetes. Diabetes Care. 2006:29(3):650-6 [PMID:16505521].

Book Chapters

  • Eliades M and Pittas AG. Vitamin D and type 2 diabetes in Holick M (editor) Vitamin D: Physiology, Molecular Biology and Clinical Applications, 2010
  • Pittas AG and Dawson-Hughes B. Vitamin D and type 2 diabetes and hypertension in Feldman D, Pike W and Adams J (editors) Vitamin D (3rd edition), pp 1907 – 1930.

Editorials

  • Mitri J and Pittas AG.  Shining a light: the role of vitamin D in diabetes mellitus. Nature Reviews Endocrinology 2010:6(9):478-80. doi: 10.1038/nrendo.2010.107 [PMID:20720588]
  • Mitri J and Pittas AG. Vitamin D therapy in adults with diabetes mellitus (Author Reply). Nature Reviews Endocrinology 2010 doi:10.1038/nrendo.2010.107-c2 [PMC Journal – In Process]
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